Dr. Fouzia Sadiq
PROFESSOR OF PHYSIOLOGY/ DIRECTOR ORIC (ACTING)
Shifa Tameer-e-Millat University, Islamabad.
PROFILE SUMMARY
Dr. Fouzia Sadiq is a Professor of Physiology and the acting Director ORIC at Shifa Tameer-e-Millat University. Prior to taking up a position in Pakistan, she worked as a post-doctoral researcher & Director Biology at Imperial College London and in Riotech Pharmaceuticals, a spin off company of Imperial College London for over a decade. With over 30 years of experience in teaching and research in the field of biological sciences and clinical translational research, Dr Sadiq possesses a broad interdisciplinary expertise. Her research has been published in high-impact international journals, including The Lancet, The Lancet-Regional Health Southeast Asia and Nature. Throughout her career she has supervised MSc, PhD, and clinical research fellows. Additionally, her CV reflects a long list of abstracts presented jointly with her students at various conferences. Currently, she is supervising three PhD students who are conducting research on Familial Hypercholesterolemia and/or Covid-19. Dr Sadiq holds the position of Pakistan Lead for the Familial Hypercholesterolemia Studies Collaboration, a worldwide project led by Professor Kausik Ray at Imperial College London. She is a Fellow of Higher Education Authority UK.
QUALIFICATION
| PhD | Molecular Physiology | The University of Aberdeen, Aberdeen, UK | 2003 |
| MRes | Biomolecular Sciences | The University of York, York, UK | 1998 |
| MSc | Zoology | The University of Punjab, Lahore, Pakistan | 1992 |
TEACHING EXPERIENCE
| Research Associate (eq Assistant Professor) | Imperial College London, London, Pakistan | 2003 – 2018 |
MANAGEMENT EXPERIENCE
| Director ORIC | Shifa Tameer-e-Millat University, Islamabad, Pakistan | 2023 – to date |
| Director International Collaborations | Shifa Tameer-e-Millat University, Islamabad, Pakistan | 2019 – to date |
| Director Research | Shifa Tameer-e-Millat University, Islamabad, Pakistan | 2018 – to date |
| Director Biology | Riotech Pharma, Imperial College London, London, UK | 2012-2013 |
MEMBERSHIP OF PROFESSIONAL BODIES
| Member | European Atherosclerosis Society, Sweden |
| Fellow | The Zoological Society of Pakistan |
| Member | Nutrition Society, UK |
HONORS & AWARDS & PROFESSIONAL SERVICES
| 1. | Gold Medal, MSc Zoology |
| 2. | Roll of Honor, BSc Biological Sciences |
| 3. | Editor “Rare Dyslipidemia” in Frontiers in Genetics |
| 4. | Editor “Epigenetics of Lp(a)” in Frontiers in Genetics and Frontiers in Cardiovascular Medicine |
| 5. | Member Editorial Board, Societal Impacts – Elsevier |
RESEARCH AREAS / INTERESTS
- Translational Research
- Familial Hypercholesterolemia (rare dyslipidemia)
- Nutrition
- Infectious diseases
- Green infrastructure and urban health
RESEARCH SUPERVISION
| 1. | PhD | Identifying the molecular basis of Familial Hypercholesterolemia in Pakistan Population |
| 2. | PhD | Investigation of Molecular Mechanisms underlying Familial Hypercholesterolemia and severe hypertriglyceridemia in cardiovascular diseases |
| 3. | PhD | Impact of Covid-19 on patients with Diabetes type II |
JOURNAL PUBLICATIONS
| 1. | The COVID-19 Host Genetics Initiative…. |
| 2. | Thursz, M., Sadiq, F., ……. (2023) Inhibition of Phosphodiesterase 12 results in Antiviral Activity against several RNA Viruses including SARS-CoV-2. J of Gen Virol. 104(7): 1-12 |
| 3. | Sadiq, F., Hegele, R.A., Catapano, A.L., Groselj, U. (2023) Editorial: Rare Dyslipidaemias. Frontiers in Genetics. 14: 1248435 |
| 4. | Sadiq, F., Shafi, S., Sikonja, J., Khan, M. et al (2023) Mapping of familial hypercholesterolemia and dyslipidemias basic management infrastructure in Pakistan: A cross-sectional study. The Lancet-regional health SouthEast Asia. |
| 5. | Dharmayat, K., ….. Sadiq, F., …… Ray, K. (2023) Global perspective of Familial Hypercholesterolemia in children and adolescents: A cross-sectional study from the EAS Familial Hypercholesterolemia Studies Collaboration. (Accepted in The Lancet) |
| 6. | Zaman, F., ….. Sadiq, F., ….. (2023) FDA-approved mPEG binds with β-catenin: An in-silico prediction for potential clinical application in patients with leukemia. (Response to reviewers’ comments submitted to In silico Pharmacology). |
| 7. | Khan, M., Majeed, S., …. Sadiq, F. (2023) Analyzing the health and psychosocial impacts of Long COVID in Pakistan: A cross sectional study. Preprint available through medRxiv |
| 8. | Ganna, A., ……. Sadiq, F (2023) A second update on mapping the human genetic architecture of COVID-19. The host genomics initiative. Nature (accepted). Preprint is available through MedRvix |
| 9. | Ain, Q., Khan, M., ….. Sadiq, F. (2023) Covid-19 vaccination symptoms and impact of covid-19 history: Cross sectional retrospective study. Preprint available at Qeios |
| 10. | Nawaz, A., Khan, M., ….. Sadiq, F. (2023) Shifa equation for calculating low density lipoprotein cholesterol. (Submitted) |
| 11. | Ain, Q., Awais, S., Khan, M., Awais, S., Raja, A.K.F., Khan, M.I., Sadiq, F. (2023) Efficacy of Paracetamol or Ibuprofen in the management of COVID-19 Fever: A Systematic Review. Journal of Islamic International Medical College. 18(1): 63-74 |
| 12. | Koponen, M., Anwaar, W., Rahman, H., Sheikh, Q., Sadiq, F. (2022) Use of artificial intelligence in coronary artery calcium scoring. Oman Medical Journal. DOI 10.5001/omj.2023.73 |
| 13. | Khan, M., Ain, Q., Nawaz, A., Khan, M.I., and Sadiq. F. (2022) Indirect calculation of LDL using thirteen equations in Pakistani population. Clin. Chimica Acta. 536:77-85 |
| 14. | Sustar, U., Groselj, U., Khan, S., Shafi, S., Khan, M.I., Kovac, J., Bizjan, B.J., Battelino, T. and Sadiq, F. (2022) A homozygous variant in the GPIHBP1 gene in a child with severe hypertriglyceridemia and a systematic literature review. Front. Genet. – Genetics of Common and Rare Diseases |
| 15. | Bhatti, M.M, Junaid, A, Sadiq, F. (2022) The Prevalence of Transfusion Transmitted Infections among Blood Donors in Pakistan: A Retrospective Study. Oman Med J. doi 10.5001/omj.2022.65 |
| 16. | Tycho, T.R., Merel L. Hartgers, Prof. G. Kees Hovingh, Antonio J. Vallejo-Vaz, Prof. Kausik K. Ray, ….. Sadiq, F et al. (2022) Homozygous Familial Hypercholesterolemia – worldwide experience. The Lancet, 6736(21): 1-10 |
| 17. | Gul, F., Aamir, R., Zehra, T., Mujtaba, H., Savul, S., Sadiq, F. (2022) Awareness of Hepatitis B, Hepatitis C and HIV among pregnant women in Pakistan. The Journal of Infection in Developing Countries, 16(9):1512-16 |
| 18. | Vallejo-Vaz, A.J., Christophe A.T. Stevens, C.A.T. ……Sadiq, F. et al. (2021) Familial Hypercholesterolemia- A global perspective from the EAS Familial Hypercholesterolemia Studies Collaboation (FHSC). The Lancet, 6736(21): 1-13 |
| 19. | Raja, A.K.F., Nazeer, M., Gul, F., Khan, M.I., Sadiq, F. (2020) Minireview: Covid-19 Therapeutics. Authorea. July 20, 2020 DOI: 10.22541/au.159526715.53659771 |
| 20. | Marusic, T., Sustar, U., Sadiq, F., Kotori, V., Mlinaric, M., Kovac, J., Shafi, S., Khan, I., Cevc, M., Podkrajsek1, K.T., Battelino, T., Groselj, U. (2020) Genetic and Clinical Characteristics of Patients With Homozygous and Compound Heterozygous Familial Hypercholesterolemia From Three Different Populations: Case Series. Front Genet [Internet]. (September):1–9. |
| 21. | Ovadia, C., Perdones-Montero, A., Spagou, K., Smith, A., Sarafian, M.H., Romero, M.G., Bellafante, E., Clarke, L.C.D., Sadiq, F., Nikolova, V., Mitchell, A., Dixon, P.H., Wahlström, A., Hayyeh, S.A., Walters, J., Marschall, H.U., Holmes, E., Marchesi, J.R., Williamson, C. (2019) Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis. Hepatology, 70(1):276-293. |
| 22. | Dhar, A, Sadiq, F., Anstee, Q. M., Levene, A.P., Goldin, R.D., Thursz, M.R. (2018) Thrombin and Factor Xa Link the Coagulation System with Liver Fibrosis. BMC Gastroenterology, 18(1): 60 |
| 23. | Ndow G, Gore, ML, Shimakawa, Y, Suso, P., Jatta, A, Tamba, S., Sow, A., Toure-Kane, C., Sadiq, F., Sabally, S., Njie, R., Thursz, M.R., Lemoine, M. (2017) Hepatitis B testing and treatment in HIV patients in The Gambia—Compliance with international guidelines and clinical outcomes. PLos One 12(6):e0179025 |
| 24. | Vergis N, Khamri, W., Beale, K., Sadiq, F., Aletrari, M.O., Moore, C., Atkinson, S.R., Bernsmeier, C., Possamai, L.A., et al (2017) Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase. Gut, 66:519-529 |
| 25. | Bernsmeier, C., Pop, O.T., Singanayagam, A., Triantafyllou, E., Patel, V.C., Weston, C.J., Curbishley, S., Sadiq, F., Vergis, N., Khamri, W., Bernal, W. et al. (2014) Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK. Gastroenterology 148(3): 603-615 |
| 26. | Robinson, O., Want, E., Coen, M., Kennedy, R., van den Bosch, C., Gebrehawaria, Y., Kudo, H., Sadiq, F., Goldin, R.D., Hauser, M.L. et al (2014) Hirmi Valley Liver Disease: A disease associated with exposure to pyrrolizidine alkaloids and DDT. J Hepatol 60(1): 96-102 |
| 27. | Sadiq, F., Crompton, L.A, Scaife, J.R., and Lomax, M.A. (2008) Effect of prolonged intravenous glucose and essential amino acid infusion on nitrogen balance, muscle protein degradation and ubiquitin-conjugating enzyme gene expression in calves. Nutr Metab (Lond). 5:5. |
| 28. | Sadiq, F., Hazlerigg, D.G. and Lomax, M. A. (2007) Amino acids and insulin act additively to regulate components of ubiquitin proteasome pathway in C2C12 muscle cells. BMC Mol Biol 8:23 |
| 29. | Lomax, M.A., Sadiq, F., Karamanlidis, G., Karamitri, A., Trayhurn, P. and Hazlerigg, D.G. (2006) Ontogenic loss of brown adipose tissue to beta adrenergic stimulation in ovine. Endocrinology 148:461-8 |
| 30. | Rehman, R., Sadiq, F., and Khan, N.R. (2000) Serum cholinesterase levels in the pesticides factory workers. Pak. J. Med. Res. 39(1):37-39 |
| 31. | Sadiq, F., Khan, N.R., Mahmud, S., and Khan, A.A. (1997) Screening for Hepatitis B virus among dental practitioners in Lahore. Int. Dental J. 47(6): 329-333 |
| 32. | Khan, N.R., and Sadiq, F. (1996) HbsAg ELISA: Comparison of serum and uncentrifuged plasma samples dried on filter paper. East African Med. J., 73(9): 592-593 |
| 33. | Khan, N.R., and Sadiq, F. (1996) Prenatal screening for Hepatitis B virus. Int. J. Gynae. & Obs. 55: 79-80 |
| 34. | Mushtaq, R., Cheema, A.M., and Sadiq, F. (1994) Effects of insulin and glucagon on free fatty acids of target tissues in dwarf goats. Pak. J. Zool., 26(1): 31-34 |
CONFERENCE PUBLICATIONS
| 1. | Sadiq, F., Khan, S., Khan, M., Shareef, A., Khan, H., Ain, Q., Khan, M.I. (2022) Potential therapeutic compounds against Hypercholesterolemia: an in-silico analysis. Accepted |
| 2. | Sadiq, F., Shafi, S., Khan, M., Ain, Q., Khan, I., Rehman, H., Sikonja, J., Mlinaric, M., Gidding, S., Groselj, U. (2022) Mapping of familial hypercholesterolemia basic infrastructure in Pakistan. Atherosclerosis 355:95 |
| 3. | Sustar, U., Groselj, U., Bizjan, J., Khan, I., Khan, S., Shafi, S., Kovac, T., Battelino, T., Sadiq, F. (2022) NGS testing of patients with dyslipidaemia revealed two patients with a homozygous GPIHBP1 variant. Atherosclerosis 355:152 |
| 4. | Marusic, T.M., Bizjan, B.J., Šuštar, U., Cevc, M., Mlinarič, M., Kovač, J., Batool, H., Khan, I., Battelino, T., Sadiq, F., U Groselj (2022) Genetic and Clinical characterisation of heterozygous and homozygous LPL deficiency: Case series. Atherosclerosis 355:80 |
| 5. | Khan, M., Ain, Q.T., Aslam, M., Khan, M.I., Sadiq, F. (2021) Patterns of Lipid profile and the risk of Familial Hypercholesterolemia in Pakistani population: A hospital-based study. J. Diabetes Endocr Pract. |
| 6. | Ain, Q.T., Khan, M., Aslam, M., Khan, M.I., Sadiq, F. (2021) Clinical outcomes of extreme phenotype COVID-19 patients with Diabetes Mellitus. J. Diabetes Endocr Pract. |
| 7. | Batool, H., Chughtai, O.R., Khan, M.D., Ashraf, S., Khan, M.I., Sadiq, F. (2021) Incidence of elevated lipoprotein (a) levels in Pakistani population. 89th European Atherosclerosis Society. Atherosclerosis |
| 8. | Batool, H., Chughtai, O.R., Khan, M.D., Rafaqat, S., Khamri, W., Sadiq, F. (2021) Characterization of Mannose Binding Lectin Levels in type 2 Diabetes Mellitus among Pakistani population. 18th WCIRDC USA conference. Metabolism |
| 9. | Gul, F., Durrani, H.M., Ashraf, S., Janjua, K., Safdar, R., Sadiq, F. (2021) Out of home eating habits of children; evidence from economically compromised settings of Islamabad, Pakistan. 10th INCHES conference, Amsterdam. Environmental research. |
| 10. | Sadiq, F., Radreau-Pierini, P., Darteil, R., Scalfaro, P., Meldrum, E., Vonderscher, J., Walters, J.R.F. (2019) Fibroblast growth factor 19 stimulation by the Farnesoid X Receptor agonist EYP001 in human ileal explants. UEG Journal 6(8S):305 |
| 11. | Kumar, N., Sadiq, F., Mukherjee, S., Khamri, W., Lebosse, F., Dhar, A., Purbhoo, M., Goldin, R., Thursz, M., Antoniades, H., Khakoo, S. (2019) The LLT1-CD161 interaction: An important inhibitory interaction for NK cells in cirrhosis. J Hepatol 70(1):E20-E21 |
| 12. | Kumar, N., Khamri, W., Sadiq, F., et al (2018) Circulating NK cells in cirrhosis are hypofunctional, with an expanded inhibitory liver-homing CD56dimCD16+/− NK cell population. J Hepatology 68:S611 |
| 13. | Kumar, N., Khamri, W., Sadiq, F., et al (2017) A Novel inhibitory NK cell subpopulation is expanded in Cirrhosis. Hepatology 66: S1 |
| 14. | Kumar, N., Khamri, W., Sadiq, F., et al (2017) Circulating Natural Killer cells in Hepatocellular Carcinoma are hypofunctional with an exhausted phenotype. Hepatology 66:S1 |
| 15. | Beale, K., Vergis, N., Sadiq, F., Petts, G., Khamri, W., Antoniades, H., Thursz, M (2015) PTH-096 Monocyte oxidative burst defect in alcoholic hepatitis is resistant to interferon gamma. Gut 64(Suppl 1):A450.1-A450 |
| 16. | Vergis N., Khamri, W., Beale, K., Sadiq, F., Atkinson, S., James, S., et al (2015) OC-021 Monocyte oxidative burst defect is associated with susceptibility to infection in severe alcoholic hepatitis. Gut 64(Suppl 1):A11.2-A12 |
| 17. | Dhar, A., Anstee, Q.M., Sadiq, F., Levene, A., Cobbold, J., Petts, G. et al (2012) A role for anticoagulation in fibrogenesis: Suppression of human hepatic stellate cell contractility and liver fibrosis in vitro and in vivo. J Hepatology 56:S35-S36 |
| 18. | Petts, G., Dhar, A., Kudo, H., Sadiq, F., Anstee, Q.M., Kallis, Y., et al (2012) OC-065 Targeted inhibition of tissue factor and thrombin on CD31 expressing cells suppresses hepatic fibrosis in CCl4 treated mice. J Hepatology 56 (Suppl 2):S157 |
| 19. | Dhar, A., Kampscheur, M, Sadiq, F et al (2011) P104 Coagulation proteins in liver fibrosis: a role for tissue factor and fibrin/fibrinogen. Gut 60(Suppl 2):A48-A48 |
| 20. | Dhar, A, Kampscheur, M, Sadiq, F, et al. (2011) Coagulation proteins in liver fibrosis: a role for tissue factor and fibrin. Gut 60 (2):A48. |
| 21. | Sadiq, F., al-Hababi, F., Matthews, I., McGarvey, M., Thomas, H. and Thursz, M. (2010) Phosphodiesterase (PDE) 12, a novel mammalian target for hepatitis C therapy. J Hepatol., 52: S298 |
| 22. | Dhar A, Anstee QM, Sadiq F, Levene A, Goldin R, Thursz MR. (2010) Factor Xa inhibition suppresses thioacetamide induced liver fibrosis. Gut 59:A33. |
| 23. | Dhar A, Anstee QM, Sadiq F, Levene A, Goldin R, Thursz MR. (2010) Factor Xa inhibition suppresses thioacetamide induced liver fibrosis. Hepatology 52:1125A |
| 24. | Chyb, S. and Sadiq, F., Robert, P.E., Chyb, M. (2006) Drosophila norpA expression in taste neurons: role in trehalose detection (AChemS XXVIII meeting abstract) Chem Senses 31(5):A21 |
| 25. | Chyb, S. and Sadiq, F. (2005) Drosophila norpA: role in insect vision and chemoreception (AACSS meeting abstract) |
| 26. | Sadiq, F. and Chyb, S. (2005) Drosophila norpA expression in gustatory neurons Comp. Biochem. Phys., 141A: S107 |
| 27. | Sadiq, F., Karamanlidis, G., Hazlerigg, D.H. and Lomax, M.A. (2004) Expression of PPAR- and PGC-1 during the transition from brown to white adipose tissue. Int. J. Obesity, 28:S103 |
| 28. | Karamanlidis, G., Sadiq, F., Hazlerigg, D.H. and Lomax, M.A. (2004) PGC-1 promoter regulation in brown and white pre-adipocytes. Int. J. Obesity, 28:S84 |
| 29. | Sadiq, F. and Lomax, M.A. (2004) Lamb fat may aid obesity battle, BBC News Online http://news.bbc.co.uk/1/hi/health/3629821.stm |
| 30. | Sadiq, F., Wallace, M.C., Struthers, J., Scaife, J.R., Birnie, L.M., Attaix, D., and Lomax, M.A. (2001) Infusion of glucose and essential amino acid down regulate the expression of components of the ubiquitin dependent proteolytic pathway in growing calves. Proc Nutr. Soc., 60:137A |
| 31. | Sadiq, F., Wallace, M.C., Struthers, J., Scaife, J.R., Birnie, L.M. and Lomax, M.A. (2001) Metabolic responses to glucose and essential amino acid infusions in calves. Proc Nutr. Soc., 60:28A |
BOOK PUBLICATIONS
| 1. | 1. Groselj, U. Hegele, R.A., Catapano, A.L., Sadiq, F. (2023) Rare dyslipidemias. Edited by U. Groselj et al. Frontiers Media SA (Frontiers Research Topics). doi:10.3389/978-2-8325-3129-7. |